a Record control number 000310520100011

a ISSN 1528-4050

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WD300

b Item number .C66 2012

a Personal name Bahceciler, Nerin Nadir

h Medium Electronic Document

a Title Comparing subcutaneous and sublingual immunotherapy: what do we know?

c Statement of responsibility, etc Nerin Nadir Bahceciler, Nilufer Galip.

b Name of publisher, distributor, etc Lippincott Williams & Wilkins

c Date of publication, distribution, etc 2012.

a Summary, etc Purpose of review Although allergen-specific sublingual (SLIT) and subcutaneous immunotherapy (SCIT) have been demonstrated to be clinically effective with similar immunological responses, head-to-head studies comparing those two modes of allergen administration in terms of onset of clinical improvement along with simultaneous immunological responses and underlying mechanisms of preventive effect are scarce. The present review will update current data on this issue. Recent findings Compared with SLIT, SCIT provides a rapid onset of clinical improvement by eliciting a simultaneous surge in production of T helper 1 (Th1) and T regulatory cell (Treg) cytokines and blocking antibodies. Similar immunological and clinical responses are evoked quite later, with no effect on Immunoglobulin G (IgG)4 levels during SLIT. Increases in TGF beta secretion due to nonrelevant allergens during SLIT may explain the preventive effect on new sensitizations. Summary SLIT and SCIT are both clinically effective in the treatment of respiratory allergic diseases with slight differences in the early phase in terms of onset of clinical efficacy and simultaneous immunological responses. Both SLIT and SCIT induce similar T-cell responses in time, but specific IgG4-blocking antibody responses are more prevalent following SCIT. Further head-to-head studies addressing the preventive effect of monotherapy and the efficacy and immunological responses of nonrelated multiallergen immunotherapy in polysensitized patients are warranted.

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Immunology

a Topical term or geographic name as entry element Allergy

a Topical term or geographic name as entry element Allergic rhinitis

a Topical term or geographic name as entry element Asthma

a Topical term or geographic name as entry element Sublingual immunotherapy

a Topical term or geographic name as entry element Grass-Pollen Extract

g Relationship information DEC 2012,Vol 12, Issue 6, p640-647

t Title Current Opinion In Allergy And Clinical Immunology

x International Standard Serial Number 1528-4050

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1097/ACI.0b013e328358d5f2