a Record control number 000259578000009

a ISSN 0931-041X

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number WJ 300

b Item number .P76 2008

a Personal name Kasap, Belde.

h Medium Electronic Document

a Title Protective effect of Epo on oxidative renal injury in rats with cyclosporine nephrotoxicity.

c Statement of responsibility, etc Belde Kasap, Alper Soylu, Filiz Kuralay, Sülen Sarioglu, Müge Kiray, Kazım Tuğyan, Mehmet Türkmen, Salih Kavukcu.

c Date of publication, distribution, etc 2008.

b Name of publisher, distributor, etc Springer,

a Place of publication, distribution, etc New York :

a Summary, etc The aim of our study was to determine the effect of recombinant human erythropoietin (rhEPO) on cyclosporine (CsA) nephrotoxicity. Twenty-six female Wistar rats were injected with 15 mg/kg subcutaneous CsA and intraperitoneal saline/rhEPO for 28 days. Four groups were formed: Group 1 (n = 5), a control group; Group 2 (n = 7), CsA + saline; Group 3 (n = 7), CsA + low dose (20 U/kg per day) rhEPO; Group 4 (n = 7), CsA + high dose (100 U/kg per day) rhEPO. Body weights, creatinine clearance, urinary protein/creatinine, hematocrit, serum creatinine levels, histopathological parameters, apoptosis and lipid peroxidation tests were compared between the three groups. Body weights and renal functions were similar in Groups 2, 3 and 4 rats but significantly lower than the values found for the control group at the end of the study. The hematocrit was significantly different between the four groups, showing a positive association with the strength of the injected rhEPO doses. Tubular and arteriolar damage was significantly lower in Groups 3 and 4 rats than in Group 2 rats, while chronic changes were similar between the three groups. TUNEL-positive cells and thiobabarbituric acid reacting substances(TBARS) levels were significantly higher in Group 2 rats, whereas superoxide dismutase levels were significantly lower in Group 2 rats than in those of the other three groups. Low or high dose rhEPO had no significant protective effects on body weight, renal functions, chronic fibrotic changes, but both doses reduced tubular and arteriolar changes, apoptotis and oxidative stress.

a Topical term or geographic name as entry element Urology & Nephrology

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Pediatrics

a Topical term or geographic name as entry element Erythropoietin Enhances Recovery

a Main entry heading Pediatric Nephrology

g Relationship information NOV 2008, Vol 23 Issue 11, p1991-1999

x International Standard Serial Number 0931041X

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1007/s00467-008-0903-1