a Record control number 000298144600011

a ISSN 1084-9785

a Original cataloging agency NEU GrandLibrary

a Language code of text/sound track or separate title eng

a Classification number QZ200

b Item number .M47 2011

a Personal name Serakıncı, Nedime,

h Medium Electronic Document

a Title Mesenchymal Stem Cells as Therapeutic Delivery Vehicles Targeting Tumor Stroma.

c Statement of responsibility, etc Nedime Serakinci, Rikke Christensen, Umut Fahrioglu, Flemming Brandt Sorensen, Frederik Dagaens-Hansen, Miroslav Hajek, Tinna Herlov Jensen, Steen Kolvraa, Nicol W. Keith.

c Date of publication, distribution, etc 2011.

b Name of publisher, distributor, etc Mary Ann Liebert Inc.,

a Place of publication, distribution, etc New Rochelle :

a Summary, etc The field of stem cell biology continues to evolve by characterization of further types of stem cells and by exploring their therapeutic potential for experimental and clinical applications. Human mesenchymal stem cells (hMSCs) are one of the most promising candidates simply because of their easiness of both ex vivo expansion in culture dishes and genetic manipulation. Despite many extensive isolation and expansion studies, relatively little has been done with regard to hMSCs' therapeutic potential. Although clinical trials using hMSCs are underway, their use in cancer therapy still needs better understanding and in vivo supporting data. The homing ability of hMSCs was investigated by creating a human xenograft model by transplanting an ovarian cancer cell line into immunocompromised mice. Then, genetically engineered hMSC-telo1 cells were injected through the tail vein and the contribution and distribution of hMSCs to the tumor stroma were investigated by immunohistochemistry and PCR specific to the telomerase gene. Results show that exogenously administered hMSCs preferentially home, engraft, and proliferate at tumor sites and contribute to the population of stromal fibroblasts. In conclusion, this study provides support for the capacity of hMSCs to home to tumor site and serve as a delivery platform for chemotherapeutic agents.

a Topical term or geographic name as entry element Oncology

a Topical term or geographic name as entry element Near East University Article

a Topical term or geographic name as entry element Yakın Doğu Üniversitesi Makale

a Topical term or geographic name as entry element Delivery vehicles

a Topical term or geographic name as entry element Mesenchymal stem cells

a Main entry heading Cancer Biotherapy And Radiopharmaceuticals

g Relationship information DEC 2011, Vol 26 Issue 6, p767-773

x International Standard Serial Number 10849785

u Uniform Resource Identifier http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1089/cbr.2011.1024