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Outcome of hypogammaglobulinemia in children: Immunoglobulin levels as predictors. (Ozen, Ahmet.)

Bibliographical information (record 266465)

Outcome of hypogammaglobulinemia in children: Immunoglobulin levels as predictors.
Author:	Ozen, Ahmet. Search Author in Amazon Books
Publisher:	Academic Press Inc Elsevier Science,

Edition:	2010.
Classification:	QW504
URL:	http://library.neu.edu.tr:2048/login?url=http://dx.doi.org/10.1016/j.clim.2010.08.010

Detailed notes

- We evaluated 131 children (M=88, F=43) with hypogammaglobulinemia Data was analyzed mainly for delineating predictor factors for outcome The distance from the lower limit of normal (-2SD) for any single measurement of immunoglobulins (Ig) was calculated and transformed into Ig scores Mean age and duration of follow up were 5 06 +/- 4 05 and 3 7 +/- 3 03 years, respectively The diagnoses were 22 CVID, 16 IgA deficiency, 33 transient hypogammaglobulinemia of childhood (THC), 3 selective IgM deficiency and 57 unclassified hypogammaglobulinemia (UCH) Low IgA scores (<-0 124) at presentation were indicative of subsequent development of IgA deficiency or CVID, whereas low IgM score (<-0 038) pointed towards more severe and persistent phenotypes Combination of low IgM score between 2 and 5 years, impaired antibody response and low B cell counts enabled us to predict persistence of hypogammaglobulinemia beyond 5 years (specificity = 90 5% and PPV = 94 9%) and chronic lung disease (sensitivity =90 4% and specificity = 68 3%) The set of criteria including low IgM scores, impaired antibody response and low B cell counts provided a high predictive value in detecting those with persistent hypogammaglobulinemia (C) 2010 Elsevier Inc All rights reserved.